When peripheral nerves are damaged, the regenerative process can result in spontaneous firing of synapses, causing chronic pain symptoms. Traditional treatments include OTC pain medications and some semi-invasive/invasive procedures. However, a significant portion of patients report minimal success with these.

Ketamine is a powerful anesthetic, but its properties as a NMDA antagonist makes it an exciting treatment opportunity for neuropathic pain. Patients report improvement in their quality of life almost immediately after the first couple of treatments. While the half-life of ketamine is only around 6 hours, with an aggressive initial treatment protocol, patients experience long lasting relief for up to twelve weeks.